Calyculin A, an enhancer of myosin, speeds up anaphase chromosome movement
نویسندگان
چکیده
منابع مشابه
Calyculin A, an enhancer of myosin, speeds up anaphase chromosome movement
Actin and myosin inhibitors often blocked anaphase movements in insect spermatocytes in previous experiments. Here we treat cells with an enhancer of myosin, Calyculin A, which inhibits myosin-light-chain phosphatase from dephosphorylating myosin; myosin thus is hyperactivated. Calyculin A causes anaphase crane-fly spermatocyte chromosomes to accelerate poleward; after they reach the poles they...
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متن کاملKinetochore-Independent Chromosome Poleward Movement during Anaphase of Meiosis II in Mouse Eggs
Kinetochores are considered to be the key structures that physically connect spindle microtubules to the chromosomes and play an important role in chromosome segregation during mitosis. Due to different mechanisms of spindle assembly between centrosome-containing mitotic cells and acentrosomal meiotic oocytes, it is unclear how a meiotic spindle generates the poleward forces to drive two rounds...
متن کاملThe Motor for Poleward Chromosome Movement in Anaphase Is in or near the Kinetochore
I have tested two contending views of chromosome-to-pole movement in anaphase. Chromosomes might be pulled poleward by a traction fiber consisting of the kinetochore microtubules and associated motors, or they might propel themselves by a motor in the kinetochore. I cut through the spindle of demembranated grasshopper spermatocytes between the chromosomes and one pole and swept the polar region...
متن کاملThe motor for poleward chromosome movement in anaphase is in or near the kinetochore
I have tested two contending views of chromosome-to-pole movement in anaphase. Chromosomes might be pulled poleward by a traction fiber consisting of the kinetochore microtubules and associated motors, or they might propel themselves by a motor in the kinetochore. I cut through the spindle of demembranated grasshopper spermatocytes between the chromosomes and one pole and swept the polar region...
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ژورنال
عنوان ژورنال: Cell & Chromosome
سال: 2007
ISSN: 1475-9268
DOI: 10.1186/1475-9268-6-1